HomeKnow SkincareCysteamine for Pores and skin: How This Antioxidant Can Assist Fade Darkish...

Cysteamine for Pores and skin: How This Antioxidant Can Assist Fade Darkish Spots

Anybody with darkish spots or melasma is aware of how difficult coping with facial discoloration may be. Many merchandise have vital unintended effects, and discovering one that will not irritate your pores and skin endlessly or bleach the areas of your face that do not have hyperpigmentation can look like trying to find a needle in a haystack. Enter cysteamine, an antioxidant that double-board-certified plastic surgeon Jaimie DeRosa, MD, tells us “is a naturally discovered chemical compound that’s biosynthesized in mammals, together with people, by the degradation of coenzyme A.” Forward, DeRosa and board-certified dermatologist Hadley King, MD, share all you’ll want to find out about cysteamine for pores and skin, from who ought to use it to the way it works.

Meet the Professional

  • Hadley King, MD is a board-certified dermatologist in New York Metropolis.
  • Jaimie DeRosa, MD, is a double-board-certified facial plastic surgeon, in addition to the founder and lead facial plastic surgeon of DeRosa Middle Plastic Surgical procedure & Med Spa in Boston and Palm Seashore.


Sort of ingredient: Antioxidant

Foremost advantages: Protected, well-tolerated, can selectively goal areas of pores and skin which have hyperpigmentation

Who ought to use it: It is protected for most individuals, together with individuals of coloration, although you should not use it in case you have vitiligo.

How typically to make use of it: It may be used day by day, and indefinitely—simply make sure to wait an hour after washing your face.

Works properly with: Vitamin C and phytic acid

Don’t use with: Different pores and skin lighteners, comparable to hydroquinone.

What Is Cysteamine?

Cysteamine is a naturally occurring antioxidant that can be utilized for lightening pigmentation within the pores and skin. “It inhibits the synthesis of melanin,” King explains. “It’s a naturally occurring antioxidant that may be discovered within the human physique.” DeRosa provides that cysteamine “has been used as a therapeutic for many years to deal with a uncommon genetic lysosomal storage dysfunction, nephropathic cystinosis.”

Cysteamine works for fading darkish patches “by reducing the quantity of L-cystine within the cells, which is concerned within the manufacturing of melanin, so it successfully works to lower extra pigmentation in pores and skin,” in response to DeRosa. She says that “that is nice for these with pores and skin circumstances together with hyperpigmentation, lentigines, post-inflammatory hyperpigmentation (PIH), and melasma.” Whereas cysteamine is of course occurring and protected for most individuals, King factors out that these with vitiligo ought to keep away from it, plus it hasn’t been examined to be used throughout being pregnant and breastfeeding, so these teams ought to steer clear as properly.

So far as who can use it, cysteamine works for all kinds of pores and skin varieties and circumstances. “Cysteamine is finest for anybody combating hyperpigmentation points, particularly those that want to keep away from hydroquinone, which is banned within the EU as a potential carcinogen, or corticosteroid-containing pores and skin lightening merchandise, which may skinny out the pores and skin,” DeRosa tells us.

Advantages of Cysteamine for Pores and skin

Whilst you do have choices with regards to substances that may assist fade pigmentation, there are a number of causes you may select cysteamine over others:

  • It is naturally occurring within the physique: Cysteamine is an antioxidant that our physique manufactures by itself. “Cysteamine is a skin-lightening agent that may be discovered within the physique’s pores and skin cells,” DeRosa explains. “This highly effective antioxidant reduces the melanin manufacturing within the pores and skin to visibly enhance cussed brown patches. Importantly, since it’s not a bleach, the pores and skin doesn’t lose the quantity of melanin (and subsequently pigment) within the pores and skin—as a substitute, it simply removes the surplus pigment that causes hyperpigmentation.”
  • Comparatively mild: So far as skin-lightening substances go, cysteamine is on the safer aspect. DeRosa says that cysteamine is “safer than different lightening merchandise accessible, together with hydroquinone (HQ).”
  • Nicely-tolerated with constant use: Cysteamine can be utilized on an ongoing foundation, and it really works properly on a variety of pores and skin tones. “It’s properly tolerated and doesn’t require ‘breaks’ in use, as in comparison with hydroquinone and corticosteroids,” DeRosa tells us. “It’s even tolerated by these with darker pores and skin varieties (so-called Fitzpatrick V and VIs).”

Facet Results of Cysteamine

Despite the fact that it is a naturally occurring antioxidant, cysteamine can nonetheless be irritating to your pores and skin, and it could actually probably trigger dryness or irritation, in response to King. To stop dryness, “it shouldn’t be utilized till an hour after cleaning with the intention to cut back this threat,” she says. “It might even be simpler to use earlier than washing, then wash it off after the required contact time. Moisturizers may help to fight dryness [as well].”

In the event you expertise a little bit of tingling or sensitivity in your pores and skin after making use of cysteamine to your pores and skin, it isn’t essentially trigger for alarm, as King says that “there may also be a brief burning sensation that can resolve inside about half an hour.” That being mentioned, if the burning is intense or does not go away, cease use and speak to your dermatologist about subsequent steps.

Tips on how to Use Cysteamine for Pores and skin

For finest outcomes, comply with the directions of no matter cysteamine product you are utilizing and/or the recommendation of your dermatologist. Some merchandise are solely left on for a short time, then washed off. King notes that regardless of the way you’re utilizing cysteamine, “rigorous solar safety must be adopted with the intention to maximize outcomes.”

“Once you add cysteamine to your skincare routine, my suggestion is to begin slowly and never combine different lively substances with it to begin simply to make sure your pores and skin tolerates it, which it ought to,” DeRosa says. “You may then add pores and skin brighteners and/or antioxidants, comparable to vitamin C and phytic acid. I’d additionally keep away from utilizing hydroquinone with this, as cysteamine ought to work as properly or higher, so no must double up.”


  • What’s cysteamine used for?

    Cysteamine’s major use is to fade pigmentation and lighten pores and skin. Not like another pores and skin lightening brokers, it’s going to solely lighten hyperpigmentation, not your entire pores and skin.

  • Does cysteamine lighten pores and skin?

    Sure, lightening areas of pores and skin with extra pigmentation is the first use of cysteamine. Nevertheless, the product is supposed to focus on darkish spots, post-inflammatory hyperpigmentation, and melasma whereas leaving your total pores and skin tone intact.

  • Is cysteamine higher than hydroquinone?

    Each cysteamine and hydroquinone are helpful for fading pigmentation and lightening pores and skin. Nevertheless, cysteamine might have fewer unintended effects than hydroquinone does.

  • Is cysteamine cream protected?

    Sure, cysteamine cream is usually thought of protected. Nevertheless, you must keep away from utilizing it if you’re pregnant or breastfeeding, or in case you have vitiligo.

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